In addition to the title, I believe that the abstract and introduction (the contents of the first page) must be similarly engaging to hold the reader’s attention. Thus, returning to the above example, the abstract could start with the sentence
“Type 1 diabetes (T1D) remains a devastating autoimmune disease for which the mechanism(s) of escape from negative selection remain largely unknown,” and then proceed to describe the details of the approach, results, and conclusion. Similarly, the introduction might start with some statistics regarding T1D incidence, mortality, and known pathology.
For bioscientific writing to retain reader interest, I prefer journals that place the Methods section at the end of the article. However, many highly respectable journals require the methods to follow the introduction. In those cases, I recommend subheadings that describe the purpose behind each method, e.g., “Isolation of CD4+CD8+ immature thymocytes for further mechanistic study of their escape from negative tolerance” and “Comparison of normal thymoctye differentiation from aberrantly developed autoimmune cells.”
Similarly, I believe subheadings within the Results section can further develop the “story” of the paper, often having a one-sentence introduction to the specific item under study, e.g., “Previous studies demonstrated downregulation of apoptosis effectors within the thymus of T1D patients.” If subheadings are not permitted, the Results sections should be written in chronological order, or from most to least important results (www.sfedit.net/results.pdf)